LIVE JOBS·83 OPEN IN SD·UPDATED OCTOBER 21, 2026
Registered Nurse (RN) jobs in South Dakota
83 open postings from 10 employers, paying a median of $36.50/hr. Most openings are in Sioux Falls, Canistota, Harrisburg.
Open postings
83
Last 45 days
Employers
10
Hiring in SD
Median hourly
$36.50
73 postings list pay
Middle 50%
$34–$40
Hourly, shift-adjusted
01·LATEST POSTINGS·50 OF 83
| Job | Location | Pay | Posted |
|---|---|---|---|
| RN - Registered Nurse - Medical Oncology - Nights Sanford Health · Fulltime | Sioux Falls, SD | $40.00/hr $1,600/wk | October 19, 2026 |
| Registered Nurse - Pediatrics Interim HealthCare · Parttime | Sioux Falls, SD | $42.00/hr $1,680/wk | October 19, 2026 |
| Registered Nurse - Home Health Care Interim HealthCare · Parttime | Sioux Falls, SD | — | October 19, 2026 |
| Registered Nurse - Intensive Care Unit US Department of Veterans Affairs · Fulltime | Sioux Falls, SD | — | October 19, 2026 |
| Registered Nurse (RN) - Infection Prevention & Control Avera Health · Fulltime | Sioux Falls, SD | — | October 19, 2026 |
| Registered Nurse (RN) OR Licensed Practical Nurse (LPN) OR Medical Assistant | Dermatology Clinic Avera Health · Fulltime | Sioux Falls, SD | $30.50/hr $1,220/wk | October 19, 2026 |
| Registered Nurse (RN) | Psychiatry Clinic | PRN Avera Health · PRN | Sioux Falls, SD | $34.00/hr $1,360/wk | October 19, 2026 |
| Registered Nurse Chiro Center One · Fulltime | Sioux Falls, SD | — | October 16, 2026 |
| Registered Nurse (RN) | Mck Surgery Avera Health · Fulltime | Sioux Falls, SD | $40.00/hr $1,600/wk | October 16, 2026 |
| Registered Nurse (RN) OR Licensed Practical Nurse (LPN) OR Medical Assistant | Comprehensive Breast Clinic Avera Health · Fulltime | Sioux Falls, SD | $30.50/hr $1,220/wk | October 15, 2026 |
| Registered Nurse (RN) | Adult Psychiatry Clinic Avera Health · Fulltime | Sioux Falls, SD | $34.00/hr $1,360/wk | October 15, 2026 |
| Registered Nurse (RN) OR Licensed Practical Nurse (LPN) OR Medical Assistant | Wound Care Clinic Avera Health · Fulltime | Sioux Falls, SD | $30.50/hr $1,220/wk | October 14, 2026 |
| Supervisor - Registered Nurse | Behavioral Health Senior Unit Avera Health · Fulltime | Sioux Falls, SD | — | October 14, 2026 |
| Registered Nurse (RN) | Palliative Medicine Prairie Center Avera Health · Fulltime | Sioux Falls, SD | $34.00/hr $1,360/wk | October 14, 2026 |
| Registered Nurse (RN) | Palliative Medicine Plaza 4 Avera Health · Fulltime | Sioux Falls, SD | $34.00/hr $1,360/wk | October 14, 2026 |
| Registered Nurse - Clinical Research Coordinator - Oncology Sanford Health · Fulltime | Sioux Falls, SD | $35.50/hr $1,420/wk | October 13, 2026 |
| RN - Registered Nurse - Ava's Hospice House - Weekends Rotating Sanford Health · Fulltime | Sioux Falls, SD | $40.00/hr $1,600/wk | October 13, 2026 |
| Registered Nurse Dakota Allergy & Asthma · Fulltime | Sioux Falls, SD | $33.50/hr $1,340/wk | October 13, 2026 |
| RN - Registered Nurse - Acute Care - PT Sanford Health · Parttime | Sioux Falls, SD | $36.50/hr $1,460/wk | October 13, 2026 |
| Registered Nurse - RN - Lactation Consultant - Child Services Sanford Health · Fulltime | Sioux Falls, SD | $37.50/hr $1,500/wk | October 13, 2026 |
| Registered Nurse (RN) Clinical Quality Analyst Avera Health · Fulltime | Sioux Falls, SD | — | October 13, 2026 |
| Registered Nurse (RN) OR Licensed Practical Nurse (LPN) - New Grad | Nursing Home | Extended Care Avera Health · Fulltime | Sioux Falls, SD | $36.00/hr $1,440/wk | October 12, 2026 |
| Registered Nurse (RN) | Endoscopy Avera Health · Fulltime | Sioux Falls, SD | $40.00/hr $1,600/wk | October 12, 2026 |
| Registered Nurse (RN) | Pre Anesthesia Call Center Avera Health · Parttime | Sioux Falls, SD | $34.00/hr $1,360/wk | October 12, 2026 |
| Registered Nurse (RN) OR Licensed Practical Nurse OR Medical Assistant | Plastic Surgery Clinic Avera Health · Fulltime | Sioux Falls, SD | $31.50/hr $1,260/wk | October 12, 2026 |
| PRN Birth Center Registered Nurse Flourish Wellness & Birth Co. · PRN | Sioux Falls, SD | — | October 9, 2026 |
| Registered Nurse (RN) - New Grad - December 2026 Avera Health · Fulltime | Sioux Falls, SD | $40.00/hr $1,600/wk | October 9, 2026 |
| Registered Nurse (RN) OR Licensed Practical Nurse (LPN) | Gastroenterology Clinic | PRN Avera Health · PRN | Sioux Falls, SD | $31.50/hr $1,260/wk | October 9, 2026 |
| Registered Nurse (RN) OR Licensed Practical Nurse (LPN) | Gastroenterology Clinic Avera Health · Fulltime | Sioux Falls, SD | $31.50/hr $1,260/wk | October 9, 2026 |
| Registered Nurse (RN) OR Licensed Practical Nurse (LPN) | Addiction Care Center Avera Health · Fulltime | Sioux Falls, SD | $36.00/hr $1,440/wk | October 9, 2026 |
| Registered Nurse (RN) OR Licensed Practical Nurse (LPN) | Behavioral Health Child Unit Avera Health · Fulltime | Sioux Falls, SD | $36.00/hr $1,440/wk | October 9, 2026 |
| Registered Nurse (RN) OR Licensed Practical Nurse (LPN) | Transitional Care Unit Avera Health · Fulltime | Sioux Falls, SD | $36.00/hr $1,440/wk | October 8, 2026 |
| Registered Nurse (RN) OR Licensed Practical Nurse (LPN) | Hematology and Transplant Clinic Avera Health · Fulltime | Sioux Falls, SD | $31.50/hr $1,260/wk | October 8, 2026 |
| Registered Nurse (RN) OR Licensed Practical Nurse (LPN) | Dawley Farm Pediatric Clinic Avera Health · Fulltime | Sioux Falls, SD | $31.50/hr $1,260/wk | October 8, 2026 |
| Registered Nurse (RN) | Surgical Renal Unit | PRN Avera Health · PRN | Sioux Falls, SD | $40.00/hr $1,600/wk | October 8, 2026 |
| Registered Nurse - RN - Neurosurgery Clinic Sanford Health · Fulltime | Sioux Falls, SD | $36.50/hr $1,460/wk | October 8, 2026 |
| Registered Nurse (RN) - Transfer Center Coordinator Avera Health · Fulltime | Sioux Falls, SD | $42.50/hr $1,700/wk | October 8, 2026 |
| Registered Nurse (RN) | Pediatric Cardiology Avera Health · Fulltime | Sioux Falls, SD | $34.00/hr $1,360/wk | October 8, 2026 |
| Registered Nurse (RN) | Rad Specials Avera Health · Fulltime | Sioux Falls, SD | $40.00/hr $1,600/wk | October 8, 2026 |
| Registered Nurse - Community Living Center US Department of Veterans Affairs · Fulltime | Sioux Falls, SD | — | October 7, 2026 |
| RN - Registered Nurse - Local Traveler Good Samaritan · Travel | Canistota, SD | $40.00/hr $1,600/wk | October 7, 2026 |
| Registered Nurse (RN) OR Licensed Practical Nurse (LPN) | Internal Medicine Clinic Avera Health · Fulltime | Sioux Falls, SD | $31.50/hr $1,260/wk | October 7, 2026 |
| Registered Nurse (RN) OR Licensed Practical Nurse (LPN) OR Medical Assistant | Obgyn Avera Health · Fulltime | Sioux Falls, SD | $30.50/hr $1,220/wk | October 7, 2026 |
| Registered Nurse (RN) OR Licensed Practical Nurse (LPN) OR Medical Assistant | Mcgreevy 7th Ave Clinic Avera Health · Fulltime | Sioux Falls, SD | $30.50/hr $1,220/wk | October 6, 2026 |
| RN - Registered Nurse - Ava's Hospice House - Weekend Days Sanford Health · Fulltime | Sioux Falls, SD | $40.00/hr $1,600/wk | October 6, 2026 |
| Registered Nurse (RN) | Mck Picc Avera Health · Parttime | Sioux Falls, SD | $40.00/hr $1,600/wk | October 6, 2026 |
| Registered Nurse (RN) | Pre-Post Operative Avera Health · Parttime | Sioux Falls, SD | $38.50/hr $1,540/wk | October 6, 2026 |
| Registered Nurse - RN - Gastroenterology Clinic Sanford Health · Fulltime | Sioux Falls, SD | $36.50/hr $1,460/wk | October 6, 2026 |
| Registered Nurse (RN) | Breast Health Clinic Avera Health · Fulltime | Sioux Falls, SD | $34.00/hr $1,360/wk | October 6, 2026 |
| Registered Nurse (RN) OR Licensed Practical Nurse (LPN) OR Medical Assistant | Harrisburg Clinic Avera Health · Fulltime | Harrisburg, SD | $30.50/hr $1,220/wk | October 6, 2026 |
02·WHERE THE JOBS ARE
| Top cities | Open jobs | Median /hr |
|---|---|---|
| Sioux Falls | 80 | $36.50 |
| Canistota | 1 | — |
| Harrisburg | 1 | — |
| Dakota Dunes | 1 | — |
| Top employers | Open jobs | Median /hr |
|---|---|---|
| Avera Health | 56 | $34.00 |
| Sanford Health | 17 | $40.00 |
| Interim HealthCare | 2 | — |
| US Department of Veterans Affairs | 2 | — |
| Chiro Center One | 1 | — |
| Dakota Allergy & Asthma | 1 | — |
| Flourish Wellness & Birth Co. | 1 | — |
| Good Samaritan | 1 | — |
| Fresenius Medical Care | 1 | — |
| Limitless Male Medical | 1 | — |
03·PAY AND NEARBY STATES
Registered Nurse (RN) salary in South Dakota →Registered Nurse (RN) salaries nationwide →
04·FREQUENTLY ASKED
How many Registered Nurse (RN) jobs are open in South Dakota?
There are 83 open Registered Nurse (RN) postings in South Dakota from 10 employers, counting postings from the last 45 days with reposts removed.
What do Registered Nurse (RN) jobs in South Dakota pay?
Open Registered Nurse (RN) jobs in South Dakota that list pay offer a median of $36.50/hr, with the middle half between $33.50 and $40.00/hr. 73 of the postings list pay.
Where are the most Registered Nurse (RN) jobs in South Dakota?
Sioux Falls, Canistota, Harrisburg have the most open Registered Nurse (RN) postings in South Dakota right now.
Who is hiring for Registered Nurse (RN) jobs in South Dakota?
Avera Health, Sanford Health, Interim HealthCare have the most open Registered Nurse (RN) postings in South Dakota.